Posology : מינונים

4.2   Posology and method of administration
Posology


The dosage has to be adjusted according to the amino acids, electrolytes, and fluid require- ments depending on the clinical condition of the patient (nutritional status and/or degree of nitrogen catabolism due to underlying disease).

Adults and adolescents from 14 to 17 years:
Daily dose:
1.0 – 2.0 g amino acids/kg body weight         ≙ 10-20 ml /kg body weight ≙ 700–1400 ml for a 70 kg patient
Maximum infusion rate:
0.1 g amino acids/kg body weight/h          ≙ 1.0 ml/kg body weight/h ≙ 1.17 ml/min for a 70 kg patient

Paediatric population

Newborn infants, infants and toddlers less than two years of age


Aminoplasmal B. Braun 10% E is contraindicated in newborn infants, infants and toddlers less than 2 years of age (see section 4.3).
Children and adolescents 2 to 13 years
The dosages for the age group stated below are average values for guidance. The exact dos- age should be adjusted individually according to age, developmental stage and prevailing disease.


Daily dose for children 2 to 4 years old:
1.5 g amino acids/kg body weight ≙ 15 ml/kg body weight
Daily dose for children 5 to 13 years old:
1.0 g amino acids/kg body weight ≙ 10 ml/kg body weight

Critically ill children:
For critically ill patients the advisable amino acid intake may be higher (up to 3.0 g amino acids/kg body weight per day).


Maximum infusion rate:
0.1 g amino acids/kg body weight/h ≙ 1.0 ml/kg body weight/h

In the case of amino acid requirements of 1.0 g/kg body weight/day or more, particular at- tention should be paid to the limitations of fluid input. To avoid fluid overload, amino acid solutions with higher amino acid content may have to be used in such situations.


Patients with renal/hepatic impairment

The doses should be adjusted individually in patients with hepatic or renal insufficiency (see also section 4.4). Aminoplasmal B. Braun 10% E is contraindicated in severe hepatic insuf- ficiency and severe renal insufficiency in absence of renal replacement therapy (see section 4.3).
Duration of use
This solution can be administered for as long as parenteral nutrition is indicated.


Method of administration
Intravenous use.
For central venous infusion only.