Interactions : אינטראקציות

4.5   Interaction with other medicinal products and other forms of interaction
Cardiac medications
Medicinal products which affect myocardial function and/or blood flow may cause false negative results in the diagnosis of coronary arterial disease. Particularly beta-blockers and calcium antagonists reduce oxygen consumption and thus also affect perfusion and beta-blockers inhibit the increase of heart frequency and blood pressure under stress. For this reason, concomitant medicinal product should be taken into consideration when interpreting the results of the scintigraphic examination. The recommendations of the applicable guidelines on ergometric or pharmacological stress tests should be followed.

Proton pump inhibitors
The use of proton pump inhibitors has shown to be significantly associated with gastric wall uptake. Its proximity to the inferior myocardial wall may lead to either false-negative or false- positive findings, and therefore to an inaccurate diagnosis. A withdrawal period for at least 3 days is recommended.



Iodine products
When the subtraction technique is used for imaging of hyperfunctioning parathyroid tissue, recent use of iodine containing radiologic contrast media, medicinal products used to treat hyper- or hypothyroidism or of several other medicinal products is likely to decrease the quality of thyroid imaging and even makes subtraction impossible. For a complete list of possibly interacting medicinal products refer to the SmPCs of sodium iodide (123I) or sodium pertechnetate (99mTc).

Paediatric population
Interaction studies have only been performed in adults.