Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

Mechanism of action
Cinnarizine is a selective calcium channel blocker. According to the WHO classification, Stunarone tablets is a class IV calcium antagonist. Cinnarizine also has an antihistaminergic (H1) action. Cinnarizine inhibits the contraction of the muscle cells of the vessel walls (anti- vasoconstrictor effect) by blocking calcium channels. In addition to this direct calcium antagonism, cinnarizine decreases the contractile activity of vasoactive substances such as norepinephrine and serotonin, by receptor-operated calcium channel blockade. Blockade of the 
cellular influx of calcium is tissue-selective and results in an anti-vasoconstrictor effect without influence on blood pressure, heart rate, cardiac contractility and conduction.
Stunarone's tablets sphere of action also extends to the brain.
Cinnarizine is further able to improve deficient microcirculation by decreasing erythrocyte deformation and blood viscosity. Cellular resistance to hypoxia is increased. Cinnarizine inhibits stimulation of the vestibular system, which results in suppression of nystagmus and other autonomic disturbances. Acute episodes of vertigo can be prevented or reduced by cinnarizine.

Pharmacodynamics
See mechanism of action.

Clinical efficacy
No data available.

Pharmacokinetic Properties