Posology : מינונים

4.2 Posology and method of administration

For administration by intravenous drip or constant rate infusion pump.
In infants with lesions restricting pulmonary blood flow (blood is flowing through the ductus arteriosus from the aorta to the pulmonary artery), Prostin VR may be administered by continuous infusion through an umbilical artery catheter placed at or just above the junction of the descending aorta and the ductus arteriosus, or intravenously.
Adverse effects have occurred with both routes of administration, but the types of Pfleet 2021-0069764                     Page 1 of 8
Prostin VR LPD CC 040821 reactions are different. A higher incidence of flushing has been associated with intra- arterial than with intravenous administration.
The infusion is generally initiated at a rate of 0.05 to 0.1 micrograms alprostadil per kilogram of body weight per minute. The most experience has been with 0.1 micrograms/kg/min. After a therapeutic response (an increase in pO2 in neonates with restricted pulmonary blood flow or an increase in systemic blood pressure and blood pH in neonates with restricted systemic blood flow) has been obtained, the infusion rate should be reduced to the lowest possible dosage that will maintain the desired response.

Paediatric population
Prostin VR contains a quantity of ethanol that is likely to affect children (see section 4.4).