Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1   Pharmacodynamic properties
Pharmacotherapeutic group: Other cough and cold preparations, ATC code: R05X 

Kaloba® Syrup contains an extract from the roots of Pelargonium sidoides, a plant which is indigenous to South Africa.
In animal experiments, inhibition of “sickness behaviour” (unspecific illness symptoms occurring in the context of an infection) and antioxidant properties could be demonstrated after oral application of the extract in mice.
In vitro, the following effects have been verified for Kaloba® syrup for children: Stimulation of unspecific defence mechanisms:
− stimulation of ciliary beat frequency of epithelial cells,
− modulation of interferon and proinflammatory cytokine synthesis,
− stimulation of activity of NK-cells
− stimulation of phagocytes, expression of adhesion molecules, chemotaxis.
Antimicrobial effects:
− moderate direct antibacterial and antiviral properties
− increase/inhibition of adhesion of A-streptococci to desquamated/living epithelial cells − inhibition of ß-lactamase.
Cytoprotective properties:
− inhibition of human leukocyte elastase
− antioxidant properties.

Pharmacokinetic Properties

5.2   Pharmacokinetic properties

Kaloba® syrup is a complex mixture of many ingredients which, as a whole, are to be considered as the active substance. Pharmacokinetic data for the individual substances are not yet available.