Special Warning : אזהרת שימוש

4.4      Special warnings and precautions for use

Adrenaline Aguettant 0.1 mg/1 ml, solution for injection in pre-filled syringe is indicated for emergency treatment. Medical supervision is necessary after administration.

In patients with a spontaneous circulation, intravenous adrenaline can cause life-threatening hypertension, tachycardia, arrhythmias and myocardial ischaemia.
Intravenous adrenaline should only be used by those experienced in the use and titration of vasopressors in their normal clinical practice. Patients who are given IV adrenaline require continuous monitoring of ECG, pulse oximetry and frequent blood pressure measurements as a minimum.

The risk of toxicity is increased if the following conditions are pre-existing • Hyperthyroidism
• Hypertension
•   Structural cardiac disease, cardiac arrhythmias, severe obstructive cardiomyopathy,
•   Coronary insufficiency
•   Phaeochromocytoma,
•   Hypokalaemia
•   Hypercalcaemia
•   Severe renal impairment
•   Cerebrovascular disease, organic brain damage or arteriosclerosis •   Patients taking Monoamine oxidase (MAO) inhibitors (see section 4.5) •   Patients taking concomitant medication which results in additive effects, or sensitizes the myocardium to the actions of sympathomimetic agents (see section 4.5)

Prolonged use of adrenaline can result in severe metabolic acidosis because of elevated blood concentrations of lactic acid.

Adrenaline may increase intra-ocular pressure in patients with narrow angle glaucoma.

Adrenaline should be used with caution in patients with prostatic hyperplasia with urinary retention.

Adrenaline may cause or exacerbate hyperglycaemia, blood glucose should be monitored, particularly in diabetic patients.

Adrenaline should be used with caution in elderly patients.

Adrenaline should not be used during the second stage of labour (See Section 4.6).
This medicinal product contains 35.4 mg sodium per syringe equivalent to 1.77% of the WHO recommended maximum daily intake of 2 g sodium for an adult.

Effects on Driving

4.7 Effects on ability to drive and use machines
Not applicable in normal conditions of use.