Special Warning : אזהרת שימוש

4.4 Special warnings and precautions for use

Adrenaline should only be administered with great caution in: elderly patients, patients with hyperthyroidism, diabetes mellitus, phaeochromocytoma, narrow angle glaucoma, hypokalaemia, hypercalcaemia, severe renal impairment and prostatic adenoma leading to residual urine, cerebrovascular disease, organic brain damage, in patients with shock (other than anaphylactic shock) and in organic heart disease or cardiac dilatation (severe angina pectoris, obstructive cardiomyopathy, hypertension) as well as most patients with arrhythmias. Anginal pain maybe induced when coronary insufficiency is present.

Repeated local administration may produce necrosis at the sites of injection.
Intramuscular injections of Adrenaline into the buttocks should be avoided because of the risk of tissue necrosis.

The IV route for injection of epinephrine must be used with extreme caution and is best reserved for specialists familiar with IV use of epinephrine (adrenaline).

Prolonged administration may induce metabolic acidosis, renal necrosis and adrenaline- fastness or tachyphylaxis.
Adrenaline should be avoided or used with extreme caution in patients undergoing anaesthesia with halothane or other halogenated anaesthetics, in view of the risk of inducing ventricular fibrillation.
Do not mix with other agents unless compatibility is known.

Adrenaline should not be used during the second stage of labour (See Section 4.6).
Accidental intravascular injection may result in cerebral haemorrhage due to the sudden rise in blood pressure.

Monitor the patient as soon as possible (pulse, blood pressure, ECG, pulse oximetry) in order to assess the response to adrenaline.

Important information about some of the ingredients of Adrenaline Sintetica 1 mg/ml 
This medicine contains less than 23 mg sodium (1 mmol) per ampoule; that is to say essentially "sodium-free".

Effects on Driving

4.7 Effects on ability to drive and use machines

Not applicable..