Posology : מינונים

4.2 Posology and method of administration

Posology
Adults and children aged 12 years and over: maximum one tablet (10 mg) per day.
Special population
Elderly
Data do not suggest that the dose needs to be reduced in elderly subjects provided that the renal function is normal.
Renal impairment
There are no data to document the efficacy/safety ratio in patients with renal impairment. Since cetirizine is mainly excreted via renal route (see section 5.2), in cases no alternative treatment can be used, the dosing intervals must be individualized according to renal function. Refer to the following table and adjust the dose as indicated. To use this dosing table, an estimate of the patient's creatinine clearance (CLcr) in mL/min is needed. The CLcr (mL/min) may be estimated from serum creatinine 


(mg/dl) determination using the following formula:
Dosing adjustments for adult patients with impaired renal function
Group                         Creatinine clearance (mL/min)              Dosage and frequency 
Normal                                                     ≥80                               10 mg once daily 
Mild                                                     50 – 79                             10 mg once daily 
Moderate                                                 30 – 49                             5 mg once daily Severe                                                   <30                            5 mg once every 2 days 
End-stage renal disease - Patients                       <10                                Contra-indicated undergoing dialysis

Hepatic impairment
No dose adjustment is needed in patients with solely hepatic impairment. In patients with hepatic impairment and renal impairment, adjustment of the dose is recommended (see Renal impairment above).
Paediatric Population
The tablet formulation should not be used in children under 6 years of age as it does not allow the necessary dose adjustments
Children aged 6-12 years: half a tablet (5 mg) twice a day in the morning and in the evening or one tablet (10 mg) once a day.
Children weighing less than 30 kg: half a tablet (5 mg) once a day.
In paediatric patients suffering from renal impairment, the dose will have to be adjusted on an individual basis taking into account the renal clearance, age and body weight of the patient.
Method of administration
The tablets need to be swallowed with a glass of liquid.