Interactions : אינטראקציות

4.5 Interactions with other medicinal products and other forms of interaction
1. NAME OF THE MEDICINAL PRODUCT                                Lidocaine should be used with caution in patients receiving other local anaesthetics or agents structurally related to
LIDOCAINE RAZ SPRAY 10%                                         amide-type local anaesthetics, e.g. antiarrhythmics such 2. QUALITATIVE AND QUANTITATIVE COMPOSITION                     as mexiletin and tocainide, since the toxic effects are
Lidocaine 10mg/metered dose.                                    additive.
Excipients with known effect: Each depression also              Specific interaction studies with lidocaine and anti- delivers 0.4mg of propylene glycol (an excipient of the         arrhythmic drugs class III (e.g. amiodarone) have not been banana essence). Also contains ethanol. For the full list of    performed, but caution is advised (see section 4.4).
excipients, see section 6.1.
Drugs that reduce the clearance of lidocaine (e.g.
3. PHARMACEUTICAL FORM                                          cimetidine or betablockers) may cause potentially toxic
LIDOCAINE RAZ SPRAY 10% is a Clear, colourless to               plasma concentrations when lidocaine is given in repeated yellowish liquid with a characteristic odour and flavor. Non-   high doses over a long time period. Such interactions sterile solution for topical application supplied in a pump     should therefore be of no clinical importance following spray, with nozzles for single use in an individual patient.    short-term treatment with lidocaine (e.g. LIDOCAINE RAZ SPRAY 10%) at recommended doses.
4. CLINICAL PARTICULARS