Special Warning : אזהרת שימוש

4.4 Special warnings and precautions for use
The solution should be clear, colourless and free of visible particles.
The pre-filled syringe is intended for a single, uninterrupted administration and any unused residual solution should be discarded.
Atropine sulfate should be used with caution in children, the elderly and patients with Down syndrome.
Precautions should be taken in geriatric patients for whom you may need a dose adjustment due to a possible occurrence of adverse events related to the cardiovascular system and the central nervous system.

Use with caution in patients with ileostomy or colostomy; the occurrence of diarrhea may indicate an incomplete intestinal obstruction.
Use with caution in cases of:
- Hyperthyroidism
- Renal or hepatic insufficiency
- Coronary alterations, acute myocardial ischemia, acute myocardial infarction, tachycardia, tachyarrhythmia.
- Obstructive uropathies
- Chronic obstructive pulmonary disease, because the reduction of bronchial secretions may lead to the formation of bronchial caps
- Urinary retention
- Fever or when the ambient temperature is high.

Cases of atrioventricular paradoxical blockade or sinus arrest have been reported following administration of atropine in some patients after cardiac transplantation. The use of atropine for therapeutic or diagnostic procedures in patients undergoing heart transplantation should be undertaken with extreme caution.

Doses of atropine up to 1 mg slightly stimulate the central nervous system. Higher doses may induce mental disorders and central nervous system depression. Children and the elderly are particularly sensitive.

Care should be taken when using atropine in the presence of ischemia, as ischemia or infarction may be worsened.

This medicinal product contains sodium. Sodium level is lower than 1 mmol per syringe, i.e.
‘without sodium’.

Effects on Driving