Interactions : אינטראקציות

4.5 Interaction with other medicinal products and other forms of interaction
Prior to starting treatment with Ospolot®, the patient should be asked about other medicines, including OTC products, he/she is using.

Influence of other medicinal products on sulthiame

Primidone
If sulthiame is combined with primidone, the intensity of undesirable effects of sulthiame may increase; especially in children, dizziness, unstable gait, drowsiness may occur.

Carbamzepine
There are indications that sulthiame serum levels may decrease if carbamazepine is taken concomitantly.

Influence of sulthiame other medicinal products

Phenytoin
If sulthiame is combined with phenytoin, the plasma levels of phenytoin can be markedly elevated.
This combination requires especially strict monitoring and frequent controls of phenytoin plasma levels, particularly in the case of impaired renal function.

Lamotrigine
In combination with lamotrigine, an elevation of lamotrigine levels in the blood has also been observed in individual cases. Therefore, lamotrigine levels should be checked more frequently at the beginning of such a treatment.

Carboanhydrase-Inhibitors
Concomitant use of sulthiame and other carbonic anhydrase inhibitors (e.g. topiramate, acetazolamide) may increase the risk of undesirable effects due to carbonic anhydrase inhibition (see also section 4.8).

Alcohol
During treatment with sulthiame, the patient should abstain from alcohol, since sulphonamides have an effect similar to that of disulfiram, and sulthiame, as a sulphonamide derivative, can theoretically have a similar effect. These symptoms include a very unpleasant, although generally self-limiting systemic reaction caused by vasodilatation, with pulsating headache, respiratory depression, nausea, vomiting, tachycardia, hypotension, amblyopia, confusion, shock reactions, arrhythmias, loss of consciousness and seizures. The degree and duration of these symptoms can vary to a great extent.