Posology : מינונים

4.2     Posology and method of administration

The dosage may vary depending on the type of examination, the age, weight, cardiac output and general condition of the patient and the technique used. Usually approximately the same iodine concentration and volume is used as with other iodinated X-ray contrast media in current use, but adequate diagnostic information has also been obtained in some studies with iodixanol injection with somewhat lower iodine concentration. Adequate hydration should be assured before and after administration as for other contrast media. The product is for intravenous, intra-arterial and intrathecal use.

The following dosages may serve as a guide. The doses given for intra-arterial use are for single injections that may be repeated.


Indication/Investigation                Concentration           Volume Intra-arterial use
Arteriographies

Adults                                    270/320 mg I/ml           40-60 ml per inj.
aortography                              270/320 mg I/ml           30-60 ml per inj.
peripheral                                 150 mg I/ml             30-60 ml per inj.
peripheral i.a.DSA                         270 mg I/ml             10-40 ml per inj.
selective visceral i.a.DSA
Cardioangiography
Adults
Left ventricle and aortic root inj.,       320 mg I/ml             30-60 ml per inj.
Selective coronary arteriography           320 mg I/ml              4-8 ml per inj.
Children                                270/320 mg I/ml          Depending on age, weight and pathology
(recommended max total dose 10 ml/kg).
Intravenous use
Urography
Adults                                    270/320 mg I/ml              40-80 ml(2) Children < 7 kg                           270/320 mg I/ml               2-4 ml/kg Children > 7 kg                             270/320 mg I/ml                 2-3 ml/kg All doses depending on age, weight and pathology (max. 50 ml).
Venography
Adults                                           270 mg I/ml                50-150 ml/leg CT-enhancement
Adults
CT of the head                             270/320 mg I/ml                 50-150 ml CT of the body                             270/320 mg I/ml                 75-150 ml Children, CT of the head and body        270/320 mg I/ml           2-3 ml/kg up to 50 ml (in a few cases up to 150 ml may be given)
Intrathecal use (adults only)
Lumbar and thoracic                          270 mg I/ml or                 10-12 ml(3) myelography                                   320 mg I/ml                    10 ml(3) (lumbar injection)

Cervical myelography                         270 mg I/ml or                 10-12 ml(3) (cervical or lumbar injection)                320 mg I/ml                    10 ml(3) 

(2) In high-dose urography higher doses can be used.
(3) To minimize possible adverse reactions a total dose of 3.2 g iodine should not be exceeded.
Elderly: As for other adults.