Adverse reactions : תופעות לוואי

4.8   Undesirable effects

Adverse reactions observed with Celestone Chronodose, which are the same as those mentioned for other corticosteroids, are related to both dose and duration of treatment.

Among the side effects of corticosteroids in general, the following effects are to be particularly noted:
Fluid and electrolyte disorders
Sodium retention - Potassium loss - Hypokalemic alkalosis - Fluid retention - Congestive heart failure in susceptible patients - Hypertension

Musculoskeletal
Muscle weakness - Loss of muscle mass - Osteoporosis - Vertebral compression fractures - Aseptic necrosis - Tendon rupture - Steroid myopathy - Pathological fracture - Instability of joints - Aggravation of myasthenic symptoms in myasthenia gravis

Gastrointestinal
Hiccups - Peptic ulcer with possible perforation and hemorrhage - Pancreatitis - Abdominal distension - Ulcerative esophagitis

Dermatological
Skin atrophy - Defective healing - Thin and fragile skin - Petechiae and bruises - Hypersensitivity reactions - Allergic dermatitis - Angioneurotic edema 
Neurological
Seizures - Increased intracranial pressure (pseudotumor cerebri) - Vertigo - Headache 
Endocrine
Irregular menstruation - Cushingoid state - Growth inhibition in children - Inhibition of pituitary-adrenal axis - Decreased glucose tolerance - Manifestations of latent diabetes mellitus - Increased requirements for insulin or oral hypoglycemic agents in diabetics 
Ophthalmic
Posterior subcapsular cataract - Increased intraocular pressure - Glaucoma - Exophthalmos- Vision blurred (see also section 4.4)

Metabolic
Negative nitrogen balance due to protein catabolism - Lipomatosis - Weight Gain 
Psychiatric
Euphoria - Unstable mood - Personality disorders and severe depression with manifestation of psychotic phenomena - Insomnia

Other
Anaphylactic or allergic reactions - Some hypotensive reactions or reactions related to shock may occur

THE FOLLOWING ADVERSE REACTIONS MAY BE OBSERVED DURING PARENTERAL
CORTICOTHERAPY:
Rare cases of blindness associated with intralesional treatment of the face and head - Hyperpigmentation or hypopigmentation - Subcutaneous and cutaneous atrophy - Sterile abscess - Post-injection exacerbation (after intra-articular use) - Charcot arthropathy 
Reporting of suspected adverse reactions
Reporting suspected adverse reactions after authorization of the medicinal product is important.
It allows continued monitoring of the benefit/risk balance of the medicinal product. Any suspected adverse events should be reported to the Ministry of Health according to the National Regulation by using an online form: https://sideeffects.health.gov.il