Quest for the right Drug
קיאקסאלאט KAYEXALATE (POLYSTYRENE SULPHONATE SODIUM)
תרופה במרשם
תרופה בסל
נרקוטיקה
ציטוטוקסיקה
צורת מתן:
פומי, רקטלי : PER OS, RECTAL
צורת מינון:
אבקה להכנת תרחיף : POWDER FOR ORAL SUSPENSION
עלון לרופא
מינוניםPosology התוויות
Indications תופעות לוואי
Adverse reactions התוויות נגד
Contraindications אינטראקציות
Interactions מינון יתר
Overdose הריון/הנקה
Pregnancy & Lactation אוכלוסיות מיוחדות
Special populations תכונות פרמקולוגיות
Pharmacological properties מידע רוקחי
Pharmaceutical particulars אזהרת שימוש
Special Warning עלון לרופא
Physicians Leaflet
Posology : מינונים
4.2 Posology and method of administration Sodium Polystyrene sulfonate is for oral or rectal administration only. The quantity of sodium polystyrene sulfonate to be administered is directly related to the level of potassium in the blood; it should therefore be adjusted to individual patient needs. As a guide: In adults Oral route: A dosage of 15 g, or 1 measuring-spoonful or 4 level teaspoonfuls, once to four times a day by oromucosal use, is commonly prescribed. Sodium polystyrene sulfonate is administered after being put in suspension in a little water. Patients may decide to add a little fruit syrup to the water. Suspension in fruit juice is not allowed, because of the latter's high potassium content. Administer Kayexalate at least 3 hours before or 3 hours after other oral medications. For patients with gastroparesis, a 6 hour separation should be considered (see sections 4.4 & 4.5). Rectal route: This route should be reserved for the patient who is vomiting or who has upper gastrointestinal tract problems, including paralytic ileus. It may be used simultaneously with the oral route for more rapid initial results or in patients with gastroparesis, who have other orally administered medications that are administered within 6 hours of Kayexalate. Sodium polystyrene sulfonate can be administered in an enema after being put in suspension in 100 ml of 10% dextrose solution at body temperature, or after mixing equal proportions of water and a 2% methylcellulose suspension. The liquid containing the sodium polystyrene sulfonate in suspension should be agitated gently during administration to ensure it remains in suspension. The enema should be retained for 4 to 10 hours if possible, followed by a cleansing enema. This operation can be repeated twice a day, if necessary. N.B.: given that ion exchange occurs mainly in the colon, it may be necessary at the beginning of treatment to start by administering the product in both an enema and by oromucosal use. A reduction in blood potassium levels will thus be achieved more rapidly and then can be sustained by oral administration. When it is necessary to pursue treatment for a long period of time, monitoring ensured by assays of blood potassium levels will enable adjustment of the effective dose. In children Oral route: Adjustments of quantity should be based on the principle that 1 g of resin eliminates1 mmol (1 mEq) of potassium. The usual initial dosage via the oral route in children is 1 g/kg body weight/day in several intakes, which can then be reduced for maintenance therapy to 0.5 g/kg body weight/day. Rectal route: When refused by mouth, Sodium polystyrene sulfonate can be administered in children via the rectal route at the same dosage as that used via the oral route and using the same methods as in adults. In newborns: Sodium polystyrene sulfonate should only be administered via the rectal route. The minimum effective dose is between 0.5 g/kg and 1 g/kg body weight/day.
שימוש לפי פנקס קופ''ח כללית 1994
Hyperkalemia
תאריך הכללה מקורי בסל
01/01/1995
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