Posology : מינונים

4.2     Posology and method of administration
Posology
Parenteral (IM or IV administration). Dalacin® C (clindamycin phosphate) must be diluted prior to IV administration and should be infused over at least 10-60 minutes.

Adults: Serious infections: 600 mg - 1.2 g/day in two, three or four equal doses.

More severe infections: 1.2-2.7 g/day in two, three or four equal doses.
Single IM injections of greater than 600 mg are not recommended nor is administration of more than 1.2 g in a single one-hour infusion.

For more serious infections, these doses may have to be increased. In life-threatening situations, doses as high as 4.8 g daily have been given intravenously to adults.

Alternatively, the drug may be administered in the form of a single rapid infusion of the first dose followed by continuous IV infusion.

Paediatric population
Children (over 1 month of age): Serious infections: 15-25 mg/kg/day in three or four equal doses.

Clindamycin should be dosed based on total body weight regardless of obesity.

More severe infections: 25-40 mg/kg/day in three or four equal doses. In severe infections it is recommended that children be given no less than 300 mg/day regardless of body weight.

Elderly patients: The half-life, volume of distribution and clearance, and extent of absorption after administration of clindamycin phosphate are not altered by increased age. Analysis of data from clinical studies has not revealed any age-related increase in toxicity. Dosage requirements in elderly patients should not be influenced, therefore, by age alone. See Precautions for other factors which should be taken into consideration 
Dosage in renal/hepatic impairment:
Clindamycin dosage modification is not necessary in patients with renal or hepatic insufficiency.


The concentration of clindamycin in diluent for infusion should not exceed 18 mg per ml and INFUSION RATES SHOULD NOT EXCEED 30 MG PER MINUTE. The usual infusion rates are as follows:

Dose            Diluent           Time
300 mg          50 ml             10 min
600 mg         50 ml             20 min
900 mg         50-100 ml         30 min
1200 mg         100 ml            40 min