Posology : מינונים

2     DOSAGE AND ADMINISTRATION
2.1     Treatment of Osteoporosis in Postmenopausal Women
The recommended dosage is one 70 mg alendronate/5600 IU vitamin D3 tablet once weekly.
2.2 Treatment to Increase Bone Mass in Men with Osteoporosis
The recommended dosage is one 70 mg alendronate/5600 IU vitamin D3 tablet once weekly.
2.3 Important Administration Instructions
Instruct patients to do the following:
• Take FOSAVANCE 70 MG/ 5600 IU TABLETS at least one-half hour before the first food, beverage, or medication of the day with plain water only [see Patient Counseling Information (17.2)]. Other beverages (including mineral water), food, and some medications are likely to reduce the absorption of alendronate [see Drug Interactions (7.1)]. Waiting less than 30 minutes, or taking FOSAVANCE 70 MG/ 5600 IU TABLETS with food, beverages (other than plain water) or other medications will lessen the effect of alendronate by decreasing its absorption into the body.
• Take FOSAVANCE 70 MG/ 5600 IU TABLETS upon arising for the day. To facilitate delivery to the stomach and thus reduce the potential for esophageal irritation, FOSAVANCE 70 MG/ 5600 IU TABLETS should be swallowed with a full glass of water (not less than 200 ml). Patients should not lie down for at least 30 minutes and until after their first food of the day. FOSAVANCE 70 MG/ 5600 IU TABLETS should not be taken at bedtime or before arising for the day. Failure to follow these instructions may increase the risk of esophageal adverse experiences [see Warnings and Precautions (5.1) and Patient Counseling Information (17.2)].
2.4 Recommendations for Calcium and Vitamin D Supplementation
Instruct patients to take supplemental calcium if dietary intake is inadequate [see Warnings and Precautions (5.2)]. Patients at increased risk for vitamin D insufficiency (e.g., over the age of 70 years, nursing home bound, or chronically ill) may need additional vitamin D supplementation. Patients with gastrointestinal malabsorption syndromes may require higher doses of vitamin D supplementation and measurement of 25-hydroxyvitamin D should be considered.
The recommended intake of vitamin D is 400 IU-800 IU daily. FOSAVANCE 70 MG/ 5600 IU TABLETS are intended to provide seven days’ worth of 800 IU daily vitamin D in a single, once-weekly dose.
2.5 Administration Instructions for Missed Doses
If a once-weekly dose of FOSAVANCE 70 MG/ 5600 IU TABLETS is missed, instruct patients to take one tablet on the morning after they remember. They should not take two tablets on the same day but should return to taking one tablet once a week, as originally scheduled on their chosen day.