Interactions : אינטראקציות

4.5   Interaction with other medicinal products and other forms of interaction
• Digoxin, cardiac glycosides
In patients under treatment with cardiac glycosides, care should be taken to keep the potassium concentration constant.
In case of hyperkalaemia - the effect of cardiac glycosides may be weakened, and in case of hypokalaemia it may result in cardiac glycoside toxicity. Interactions might occur in the concurrent administration of other antiarrytmics. Potassium administration must be very carefully discontinued in these patients.
●    Drugs with the potential to induce hyperkalaemia
Care should be taken in the concurrent use of drugs containing potassium, potassium-sparing diuretics, and drugs with a potential to induce hyperkalaemia, such as: -spironolactone
-triamterene
-ACE inhibitors
-Angiotensin II receptor antagonists
-non-steroidal anti-inflammatory agents
-ciclosporin
-tacrolimus
-suxamethonium
The concomitant administration of potassium-containing solutions and these drugs may lead to severe hyperkalaemia, which may in turn lead to cardiac arrhythmia.
The concomitant use of sodium-retaining drugs (e.g. corticosteroids, non-steroidal anti- inflammatory agents) may lead to oedema.
●  Drugs leading to a decrease of the serum potassium level
ACTH, corticosteroids and loop diuretics can increase the renal elimination of potassium.