Posology : מינונים

4.2. Posology and method of administration                       1 year of age, the elderly over sixty years who have a
Adults                                                           reduced clearance), congestive heart failure, chronic The treatment is reserved to severe cases of bronchial           obstructive lung affections and related infections, fever asthma through a slow infusion of a solution obtained by         (a temperature of 39°C or higher for 24 hours or more, diluting 480 mg of Aminophylline (equal to 2 ampoules            or a lower temperature but for longer periods), of Aminophylline S.A.L.F. 240 mg/10 ml) in 50 ml of a            hypothyroidism, liver disease (cirrhosis, acute compatible solution for infusion (e.g. saline solution,          hepatitis), acute pulmonary edema, sepsis, shock, and glucose solution).                                               the concomitant administration of certain drugs (see The infusion rate of the solution should not exceed 3.6 ml/min   section 4.5 "Interaction with other medicinal products (equal to 25 mg of Aminophylline/minute).                        and other forms of interaction"). In the presence of The total administered dose should not exceed 0.8 ml/kg          these factors, it is recommended to monitor blood (equal to 5.6 mg of Aminophylline/kg).                           levels of Aminophylline considering that its therapeutic This infusion can be followed by another maintenance             values are 10-15 µg/ml and the minimum toxic dose 20 infusion obtained by diluting 240 mg of Aminophylline (equal     µg/ml.
to 1 ampoule of Aminophylline S.A.L.F. 240 mg/10 ml) in
500 ml of a solution for infusion (see above).                   Important information about some of the ingredients: The infusion rate for the maintenance solution should be:        None.
- 1.9 ml/kg/hour (equal to 0.9 mg of
Aminophylline/kg/hour) in smoking adults                  4.5. Interaction with other medicinal products and below 50 years.                                                other forms of interaction - 0.9 ml/kg/hour (equal to 0.45 mg/kg/hour) in no             Drugs that may decrease the hematic concentration of smoking adults below 50 years.                            Aminophylline and consequently reduce its - 0.5 ml/kg/hour (equal to 0.25 mg/kg/hour) in adults         effectiveness: adenosine, barbiturates, butalbital, with heart failure or hepatic impairment.                 cannabis, carbamazepine, felodipine, phenytoin, In any case, the intravenous administration of the product       phenobarbital, smoke of cigarette, furosemide, should be carried out with the patient in supine position,       hypericum, isoniazid, nifedipine, pancuronium, at a controlled slow rate (15-20 minutes).                       primidone, rifampicin, rifapentine, ritonavir, sulfinpyrazone, terbutaline.
Children
The dosage in children below 9 years is 1 mg/kg/hour.            Drugs that may increase the hematic concentration of aminophylline and consequently increase its toxicity':
Do not use the solution in presence of crystallization.          pipemidic acid, albendazole, allopurinol, amiodarone, Inject slowly.                                                   anagrelide, bupropion, cimetidine, clarithromicyn, clindamycin, oral contraceptives, diltiazem, disulfiram,