Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1. Pharmacodynamic properties

Pharmacotherapeutic group (ATC code): B05BB01 “Electrolytes”.
RINGER LACTATED SOLUTION is an isotonic solution of electrolytes. The constituents of RINGER LACTATED SOLUTION and their concentrations are designed to match those of plasma.
The pharmacological properties of the RINGER LACTATED SOLUTION those of its components (sodium, potassium, calcium, chloride and lactate).
The main effect of RINGER LACTATED SOLUTION is the expansion of the extracellular compartment including both the interstitial fluid and the intravascular fluid.
The lactate is metabolised into bicarbonate, mainly in the liver, and produces an alkalinising effect on the plasma.
In healthy volunteers receiving RINGER LACTATED SOLUTION,central venous pressure changes were associated with a secretion of atrial natriuretic peptide.
In healthy volunteers, RINGER LACTATED SOLUTION decreased serum osmolality, increased blood pH, and the time until first urination was shorter than that with normal saline.
There is no significant changes in glucagon, norepinephrine, epinephrine, blood glucose and insulin levels in aortic surgery patients receiving RINGER LACTATED SOLUTION.
When medication is added to RINGER LACTATED SOLUTION,the overall pharmacodynamics of the solution will depend on the nature of the drug used.

Pharmacokinetic Properties

5.2. Pharmacokinetic properties

The pharmacokinetic properties of the RINGER LACTATED SOLUTION are those of the ions its composition includes (sodium, potassium, calcium and chloride).
Infusion of RINGER LACTATED SOLUTION in normalhemodynamically stable adults does not increase circulating lactate concentrations.
The pharmacokinetics of D-lactate and L-lactate are similar.
The lactate in RINGER LACTATED SOLUTION is metabolized by both oxidation and gluconeogenesis, predominantly in the liver, and bicarbonate is generated by both processes over 1-2 h.
When medication is added to RINGER LACTATED SOLUTION,the overall pharmacokinetics of the solution will depend on the nature of the drug used.