Posology : מינונים

4.2    Posology and method of administration
Adults
The recommended dosage for Bezafibrate Medomie is one tablet, equivalent to 400mg bezafibrate and should be swallowed whole with sufficient fluid after a meal either in the morning or at night.

Elderly
In elderly patients there is a physiological reduction of the renal function with age.
Bezafibrate Medomie should not be prescribed/administered to older people whose creatinine clearance is below 60ml/min (see Renal impairment below).

Paediatric population
At present there is inadequate information regarding an appropriate dose recommendation in children.

Renal impairment
Bezafibrate Medomie is contraindicated in dialysis patients. Bezafibrate should not be given to patients with renal impairment with serum creatinine > 135 micromol/l or creatinine clearance < 60 ml/min. Such patients may be treated with conventional tablets (200mg Bezafibrate) using an appropriately reduced daily dosage.
For patients with a history of gastric sensitivity, the dosage may be gradually increased over 5-7 days to the maintenance level.
The response to therapy is normally rapid, although a progressive improvement may occur over a number of weeks. Treatment should be withdrawn if an adequate response has not been achieved within 3 to 4 months.