Contraindications : התוויות נגד

4.3   Contraindications
Articaine HCl 4% and Epinephrine 1:100,000 is not allowed to be used in the event of
- children under 4 years of age
- hypersensitivity to the active substances, sodium sulphite (E221) or to any of the other excipients
Due to the local anaesthetic ingredient articaine, Articaine HCl 4% and Epinephrine 1:100,000 is not allowed to be used in the event of − known allergy or hypersensitivity to local anaesthetics of the amide type − severe impairment of the impulse initiation and conduction system of the heart (e.g. grade II and
III AV block, pronounced bradycardia)
− acutely decompensated cardiac insufficiency
− severe hypotension
− patients who are known to have a deficiency in plasma cholinesterase activity
− haemorrhagic diatheses – particularly with nerve-block anaesthesia − injection into an inflamed area
Due to the content of epinephrine as a vasoconstrictor admixture, Espestesin 4 % articaine with 1:100,000 adrenaline (epinephrine) is not allowed to be used in the event of
− Heart diseases such as:
- unstable angina pectoris
- recent myocardial infarction
- recent coronary artery bypass surgery
- refractory arrhythmias and paroxysmal tachycardia or high-frequency, continuous arrhythmia
- untreated or uncontrolled severe hypertension
- untreated or uncontrolled congestive heart failure
- concomitant treatment with monoamine oxidase (MAO) inhibitors or tricyclic antidepressants (see section 4.5)
Due to the content of sulphite as excipient, Espestesin 4 % articaine with 1:100 000 adrenaline (epinephrine) is not allowed to be used in the event of - allergy or hypersensitivity to sulphite
- severe bronchial asthma
Articaine HCl 4% and Epinephrine 1:100,000 can provoke acute allergic reactions with anaphylactic symptoms (e.g. bronchospasm).