Posology : מינונים

4.2.   Posology and method of administration

Adults, children and neonates: severe and immunocompromised infections, 50mg/kg/day, preferably by continuous infusion (equivalent to 4g per day for adults).
Mild to moderate infections (oral route compromised); 25mg/kg/day.

Elderly: No special dosage recommendations.

Recommended Administration
Bolus injection (IV) push) is contraindicated

Continuous infusion of erythromycin lactobionate is preferred due to the slower infusion rate and lower concentration of erythromycin; however, intermittent infusion at intervals not greater than every six hours is also effective.
Intravenous erythromycin should be replaced by oral erythromycin as soon as possible.

Preparations for administration:

For Intermittent Infusion of 1 gram dose:
Step 1 - add 20 ml of Water for Injections BP to the 1 g vial.
Step 2 - add 20 ml of Step 1 solution to 200-250 ml of Sodium Chloride Intravenous Infusion BP (0.9% Saline). This provides a 0.5%-0.4% solution.


If it is decided to administer the daily dose as an intermittent infusion, then the erythromycin concentration should not exceed 5 mg/ml and the time of each infusion should be between 20 and 60 minutes.

For Continuous Infusion of 1 gram dose:
Step 1 - add 20 ml of Water for Injections BP to the 1 g vial.
Step 2 - add 20 ml of Step 1 solution to 500-1000 ml of Sodium Chloride Intravenous Infusion BP (0.9% Saline). This provides a 0.2%-0.1% infusion.

The infusion should be completed within eight hours of preparation to ensure potency.

Alternative Step 2 diluents:
Compound Sodium Lactate Injection BP (Hartmann’s Solution).
Solutions containing glucose may also be used but sodium bicarbonate must first be added as a buffer to ensure neutrality.
5ml of sterile 8.4% w/v sodium bicarbonate solution will neutralise one litre of: Glucose Injection BP (5%), or of Sodium Chloride and Glucose Injection BP (usually 0.18% sodium chloride and 4.0% glucose).
The stability of solutions of this medicine is adversely affected below pH 5.5.

For further details please see section 6.6.