Posology : מינונים

4.2 Posology and method of administration

Phenylephrine Sintetica 0.1 mg/ml should only be administered by physicians with appropriate training and experience.
In case of caesarean section, administration should only be done intravenously Phenylephrine Sintetica 0.1 mg/ml is also available in the galenic form of already diluted solution (ready to use) for administration by continuous intravenous infusion or bolus injection (Phenylephrine Sintetica 0.1 mg/ml).
For patients with paroxysmal supraventricular tachycardia and if indicated in an emergency, administer Phenylephrine Sintetica 0.1 mg/ml intravenously. The dose should be adjusted to the blood pressure response.


Mild or moderate hypotension
Phenylephrine Sintetica 0.1 mg/ml, solution for injection/solution for infusion (ready to use) Slow intravenous injection or intravenous infusion:
Calculation of the dose
Dose required      Use of Phenylephrine Sintetica 0.01%
(0.1 mg/ml)
50 µg              0.5 ml
75 µg              0.75 ml
100 µg             1 ml


Slow intravenous bolus injection:
The usual dose is 50 µg (0.5 ml Phenylephrine Sintetica 0.1 mg/ml), which can be repeated until the desired effect is achieved. In case of severe hypotension, the doses can be increased without exceeding the bolus dose of 100 µg (1 ml Phenylephrine Sintetica 0.1 mg/ml).

Continuous infusion:
The initial dose is 25-50 µg/min, up to 180 µg/min. The doses can be increased or decreased to keep the systolic blood pressure level near normal. Doses between 25 and 100 µg/min (0.25 ml – 1.0 ml Phenylephrine Sintetica 0.1 mg/ml per minute) have been considered effective.


Significant hypotension and shock, including drug-induced hypotension Before administration of vasopressors, volume depletion should always be corrected as far as possible.
When the intra-aortic pressure must be maintained in an emergency to avoid ischemia of the cerebral or coronary arteries, Phenylephrine Sintetica 0.1 mg/ml can be administered before and during volume filling.
Overdose and idiosyncrasy after administration of certain medicinal products, beta-adrenergic and ganglionic blockers, Rauwolfia and veratrum alkaloids and phenothiazine tranquillizers, in particular, can cause hypotension and occasionally severe shock. Patients receiving a phenothiazine derivative before surgery are particularly susceptible to these types of reactions. In the treatment of this type of reaction, Phenylephrine Sintetica 0.1 mg/ml is an appropriate adjunctive treatment for restoring blood pressure.
In patients with severe hypotension or prolonged or untreated shock, higher initial and maintenance doses of Phenylephrine Sintetica 0.1 mg/ml are required. Intensive treatment may also be necessary for hypotension triggered by strong peripheral beta-adrenergic blockers, by chlorpromazine, or by removal of a pheochromocytoma.


Spinal anaesthesia – hypotension

Phenylephrine Sintetica 0.1 mg/ml
Intravenous route
In an emergency, during episodes of hypotension during spinal anaesthesia, Phenylephrine Sintetica 0.1 mg/ml can be administered intravenously at an initial dose of 0.2 mg (2 ml Phenylephrin Sintetica 0.1 mg/ml).
None of the subsequent doses should be more than 0.1 mg to 0.2 mg higher than the previous dose (1 ml to 2 ml Phenylephrine Sintetica 0.1 mg/ml), and each dose should be lower than 0.5 mg (5 ml Phenylephrin Sintetica 0.1 mg/ml)

Paroxysmal supraventricular tachycardia
Phenylephrine Sintetica 0.1 mg/ml
Rapid intravenous injection
A rapid intravenous injection (in 20-30 seconds) is recommended. The initial dose should not exceed 0.5 mg (5 ml Phenylephrine Sintetica 0.1 mg/ml) and subsequent doses, which depend on the initial blood pressure reaction, should not be more than 0.1 to 0.2 mg higher than the previous dose, and never exceed 1 mg (10 ml Phenylephrine Sintetica 0.1 mg/ml).

Children and adolescents:
The use and safety of Phenylephrine have not been studied to date in children and adolescents. For this reason, use in children and adolescents is not recommended.