Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1 Pharmacodynamic properties
LIPID EMULSION FOR PARENTERAL NUTRITION
(B05BA02)

The combination of olive and soybean oils allows a content of fatty acids in an approximate ratio of: 
–    Saturated fatty acids: 15% (SFA)
–    Mono-unsaturated fatty acids: 65% (MUFA)
–    Essential Poly-unsaturated fatty acids: 20% (EPUFA)

The moderate level of essential fatty acids (EFA) facilitates their utilisation, enables a correct status of EFA upper derivatives and corrects EFA deficiency. This property has been verified for doses ranging from 1 to 3 g/kg/day.

The high energy content of the emulsion enables the administration of a large quantity of calories in a small volume.

Pharmacokinetic Properties

5.2. Pharmacokinetic properties

At physiologic doses, the elimination kinetics of serum triglycerides of ClinOleic 20% are comparable to those of natural chylomicrons. Fatty acids generated from triglyceride hydrolysis can be used as an energy source, stored in adipose tissue or incorporated in different types of cell membranes, depending on the individual needs.