Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1       Pharmacodynamic properties

Pharmacotherapeutic group: Prostaglandins, ATC-code: G02AD02

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Dinoprostone is a prostaglandin of the E series with actions on smooth muscle; the endogenous substance is termed prostaglandin E2. It induces contraction of uterine muscle at any stage of pregnancy and is reported to act predominantly as a vasodilator on blood vessels and as a bronchodilator on bronchial muscle. It is postulated that vaginal absorption of PGE2 stimulates endogenous PGE2 and PGF2α production, similar to that which is seen in spontaneous labour.

Pharmacokinetic Properties

5.2     Pharmacokinetic properties
Following insertion of the tablet, PGE2 absorption (as measured by the presence of PGE2 metabolites) increases to reach a peak at about 40 minutes. PGE2 is rapidly metabolised to 13, 14-dihydro, 15-keto PGE2 which is converted to 13, 14-dihydro, 15-keto PGA2 which binds covalently to albumen.

There has been found to be inter-patient variability regarding systemic absorption of PGE2. This can be attributed to different conditions of the vaginal mucosa between patients.