Special Warning : אזהרת שימוש

4.4 Special warnings and precautions for use
Parenterally administered iron or iodine preparations can cause hypersensitivity reactions on rare occasions, including serious and potentially fatal anaphylactic reactions.
Patients should be clinically observed for signs and symptoms of hypersensitivity reactions. In case of hypersensitivity reactions, the infusion should be stopped immediately and appropriate measures performed.
If iron is taken orally in parallel with infusion of Addaven, the total intake of iron should be determined to ensure that there is no iron accumulation.
Addaven should be used with caution in patients with liver dysfunction. Liver dysfunction, including impaired biliary excretion, may interfere with excretion of trace elements from Addaven, leading to a risk of accumulation.
Addaven should be used with caution in patients with impaired renal function as excretion of some trace elements in urine may be significantly decreased.
If the treatment is continued for more than 4 weeks, checking trace element levels in plasma, especially manganese, is required.
If an individual patient has a markedly increased requirement for any of the trace elements, the regimen can be adjusted using separate supplements.

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