Posology : מינונים

4.2     Posology and method of administration

The dosage vary depending on the type of examination age, weight, cardiac output and general condition of the patient and the technique used. Usually, the same iodine OMNIPAQUE        Injection X-ray contrast medium concentration and volume is used as with other iodinated X-ray contrast media in current use. Adequate hydration should be assured before and after administration as for other contrast media.
For intravenous, intra-arterial and intrathecal use, and use in body cavities.
The following dosages may serve as a guide:

Guidelines for intravenous use

Indication            Concentration                Volume                    Comments Urography
 adults:                 300 mg I/ml             40 - 80 ml                   80 ml may be or 350 mg I/ml          40 - 80 ml                   exceeded in selected cases children < 7 kg         240 mg I/ml             4 ml/kg b.w.
or 300 mg I/ml          3 ml/kg b.w.
 children > 7 kg         240 mg I/ml             3 ml/kg b.w.
or 300 mg I/ml          2 ml/kg b.w.
(max 40 ml)

Phlebography (leg)      240 mg I/ml             20 - 100 ml/leg or 300 mg I/ml


Digital subtraction     300 mg I/ml             20 - 60 ml/inj.
angiography             or 350 mg I/ml          20 - 60 ml/inj.
CT-enhancement adults:                 240 mg I/ml             100 - 250 ml                 Total amount of or 300 mg I/ml          100 - 200 ml                 iodine or 350 mg I/ml          100 - 150 ml                 usually 30 - 60 g  children:               240 mg I/ml             2-3 ml/kg b.w. up to 40 ml   In a few cases up to or 300 mg I/ml          1-3 ml/kg b.w. up to 40 ml   100 ml may be given 

Guidelines for intra-arterial use

Indication             Concentration               Volume                    Comments 
Arteriographies
 arch aortography         300 mg I/ml             30 - 40 ml/inj.              Volume per injection selective cerebral       300 mg I/ml              5 - 10 ml/inj.              depends on the site aortography              350 mg I/ml             40 - 60 ml/inj.              of injection femoral                  300 mg I/ml             30 - 50 ml/inj.
or 350 mg I/ml
 various                  300 mg I/ml             depending on type of examination



OMNIPAQUE        Injection X-ray contrast medium

Indication             Concentration                Volume             Comments 
Cardioangiography
 adults: left ventricle and       350 mg I/ml             30 - 60 ml/inj.
aortic root inj.
selective coronary       350 mg I/ml              4 - 8 ml/inj.
arteriography depending on age,
children:                300 mg I/ml             weight and pathology or 350 mg I/ml          (max 8 ml/kg b.w.)
 depending on site of
Digital subtraction      240 mg I/ml              1 - 15 ml/inj.        inj. occasionally large angiography              or 300 mg I/ml           1 - 15 ml/inj.        volumes - up to 30 ml - may be used

Guidelines for intrathecal use

Indication              Concentration            Volume                 Comments 
Lumbar and              240 mg I/ml               8 – 12 ml thoracic myelography
(lumbar injection)

Cervical                240 mg I/ml              10-12 ml myelography             or 300 mg I/ml            7 - 10 ml
(lumbar injection)
Cervical                240 mg I/ml              6 - 10 ml myelography             or 300 mg I/ml           6 - 8 ml
(lateral cervical injection)

CT cisternography       240 mg I/ml              4 - 12 ml
(lumbar injection)



To minimize possible adverse reactions a total dose of 3 g iodine should not be exceeded.
Guidelines for body cavities


Indication              Concentration            Volume                 Comments 
Arthrography               300 mg I/ml           5 - 15 ml or 350 mg I/ml           5 - 10 ml

OMNIPAQUE    Injection X-ray contrast medium

ERP/ERCP                240 mg I/ml              20 - 50 ml

Herniography            240 mg I/ml              50 ml                     The dosage varies with the size of the hernia


Hysterosalpingog         240 mg I/ml             15 - 50 ml raphy                 or 300 mg I/ml             15 - 25 ml

Sialography              240 mg I/ml             0.5 - 2 ml or 300 mg I/ml             0.5 - 2 ml

Gastrointestinal studies
Oral use
Adults:                350 mg I/ml              Individual                Max. dose 50 ml Max. dose 50 ml

Children:
- oesophagus             300 mg I/ml             2-4 ml/kg b.w.
or 350 mg I/ml             2-4 ml/kg b.w.

Prematures:            350 mg I/ml              2-4 ml/kg b.w.
Rectal use
- children:           dilute with tap-water to   5-10 ml/kg b.w.
100-150 mgI/ml                                       Example:
Dilute Omnipaque
240, 300 or 350 with tap-water 1:1 or 1:2

CT- enhancement

Oral use
- adults:             Dilute with tap water to   800-2000 ml of the        Example: ~6mgI/ml                   diluted solution over a   Dilute Omnipaque period of time            300 or 350 with tap water 1:50
- children:           Dilute with tap water to   15-20 ml/kg b.w. of the ~6mgI/ml                   diluted solution

Rectal use
- children:           Dilute with tap water to   individual
~6mgI/ml

For elderly patients, patients with hepatic and/or renal impairments, the usual/proposed doses for adults can be used.