Posology : מינונים

4.2   Posology and method of administration

In an emergency or for rapid effect, or as a slow intravenous infusion when prolonged administration is required.
a) Bolus injection: Administer 2 mg/kg over not less than ten minutes, or in divided doses.
Alternatively dilute with 5% dextrose and give as a mini-infusion.
Continuous ECG monitoring is recommended. Stop the injection when the arrhythmia is controlled.
For sustained ventricular tachycardia, or people with a history of cardiac failure (who may become decompensated during administration) give the initial dose over 30 minutes and monitor the ECG carefully.
The maximum recommended bolus dose is 150 mg.
b) Intravenous infusion: The recommended procedure is to start with a slow injection of 2 mg/kg over 30 minutes, then continue intravenous infusion at the following rates: First hour: 1.5 mg/kg per hour.
Second and later hours: 0.1 - 0.25 mg/kg per hour.
The maximum recommended infusion duration is 24 hours; if exceeded, and in patients receiving high doses, monitor plasma levels.
The maximum cumulative dose over the first 24 hours should not exceed 600 mg.
In severe renal impairment (creatinine clearance < 35 ml/min/1.73 sq.m.) reduce the above dosage recommendations by half.
Oral maintenance dosing should be started as soon as possible after stopping the infusion.

Children: Tambocor is not recommended in children under 12, as there is insufficient evidence of its use in this age group.

Elderly Patients: The rate of flecainide elimination from plasma may be reduced in elderly people. This should be taken into consideration when making dose adjustments.