Interactions : אינטראקציות

4.5         Interaction with other medicinal products and other forms of interaction
Clinical studies have demonstrated that PRIORIX can be given simultaneously with any of the following monovalent or combination vaccines [including hexavalent vaccines (DTPa-HBV- IPV/Hib)]: diphtheria-tetanus-acellular pertussis vaccine (DTPa), reduced antigen diphtheria- tetanus-acellular pertussis vaccine (dTpa), Haemophilus influenzae type b vaccine (Hib), inactivated polio vaccine (IPV), hepatitis B vaccine (HBV), hepatitis A vaccine (HAV), meningococcal serogroup B vaccine (MenB), meningococcal serogroup C conjugate vaccine (MenC), meningococcal serogroups A, C, W-135 and Y conjugate vaccine (MenACWY), varicella zoster vaccine (VZV), oral polio vaccine (OPV) and pneumococcal conjugate vaccine in accordance with local recommendations.

Due to an increased risk of fever, tenderness at the injection site, change in eating habits and irritability when Bexsero was co-administered with a combined measles-mumps-rubella- varicella (MMR-V) vaccine, separate vaccination with PRIORIX can be considered when possible.

There are no data to support the use of PRIORIX with any other vaccines.

If PRIORIX is to be given at the same time as another injectable vaccine, the vaccines should always be administered at different injection sites.

If not given at the same time, an interval of at least one month is recommended between administration of PRIORIX and other live attenuated vaccines.

If tuberculin testing has to be done it should be carried out before or simultaneously with vaccination since it has been reported that combined measles, mumps and rubella vaccines may cause a temporary depression of tuberculin skin sensitivity. As this anergy may last up to a maximum of 6 weeks, tuberculin testing should not be performed within that period after vaccination to avoid false negative results.

In subjects who have received human gammaglobulins or a blood transfusion, vaccination should be delayed for three months or longer (up to 11 months) depending on the dose of human globulins administered because of the likelihood of vaccine failure due to passively acquired measles, mumps and rubella antibodies.