Interactions : אינטראקציות

4.5 Interaction with other medicinal products and other forms of interaction
The blood concentration of filterable/dialysable drugs may be reduced during treatment.
Corresponding corrective therapy should be instituted if necessary to establish the desired blood concentrations for drugs removed during treatment.

Interactions with other medications due to electrolyte and/or acid-base imbalances can be avoided by correct dosage of the solution for haemodialysis/haemofiltration and precise monitoring.

However, the following interactions are conceivable:
• The risk of digitalis-induced cardiac arrhythmia is increased during hypokalaemia;
• Vitamin D and vitamin D analogues, as well as medicinal products containing calcium (e.g.
calcium chloride or calcium gluconate used for maintenance of calcium homeostasis, in CRRT patients receiving citrate anticoagulation and calcium carbonate as phosphate binder) can increase the risk of hypercalcaemia;
• Additional sodium hydrogen carbonate (or other buffer source) contained in the CRRT fluids or in other fluids administered during therapy may increase the risk of metabolic alkalosis;
• When citrate is used as an anticoagulant, it contributes to the overall buffer load and can reduce plasma calcium levels.