Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1 Pharmacodynamic properties

ATC code: D06AX01

Fucidin Cream & Fucidin Ointment contain fusidic acid/ sodium fusidate respectively, potent topical antibacterials. Fusidic acid and its salts exhibit fat and water solubility properties with strong surface activity, and show unusual ability to penetrate intact skin. However, they are poorly systemically absorbed after topical administration. Concentrations of 0.03 - 0.12 mcg/ml inhibit nearly all strains of Staphylococcus aureus. Topical Fucidin® is also active against Streptococci, Corynebacteria, Neisseria and certain Clostridia.

Pharmacokinetic Properties

5.2 Pharmacokinetic properties
There are no data which define the pharmacokinetics of Fucidin® Cream and Fucidin® Ointment, following topical administration in man.
However, in vitro studies show that fusidic acid and its salts can penetrate intact human skin in concentrations well above the MIC-values of susceptible organisms. The degree of penetration depends on factors such as the duration of exposure to fusidic acid (or its salts) and the condition of the skin. Fusidic acid and its salts are excreted mainly in the bile with little excreted in the urine.