Posology : מינונים

4.2   Posology and method of administration
The therapy with argipressin in patients with catecholamine refractory hypotension is slowly started by a continuous intravenous infusion of 0.01 I.U. per minute using a perfusor / motor pump.
Dependent on the clinical response, the dose may be increased every 15 – 20 minutes up to 0.03 I.U. per minute. For intensive care patients, the usual target blood pressure is 65 – 75 mmHg. Argipressin should only be used in addition to conventional vasopressor therapy with catecholamines. Doses above 0.03 I.U. per minute should only be applied as emergency treatment, as this may cause gut and skin necrosis (see section 4.4).
Dose reductions of Embesin should be done in accordance with the clinical course. The treatment duration should also be chosen according to the individual clinical picture.


The solution for infusion is prepared by diluting 40 I.U. Embesin with NaCl 9 mg/ml (0.9%) solution. The total volume after dilution should be 50 ml (equivalent to 0.8 I.U. argipressin per ml).

Infusion rates according to the recommended doses:
Dose Embesin / min                  Dose Embesin / hour                     Infusion rate 


0.01 I.U.                             0.6 I.U.                              0.75 ml / hour 0.02 I.U.                             1.2 I.U.                              1.50 ml / hour 0.03 I.U.                             1.8 I.U.                              2.25 ml / hour 
Paediatric population
Embesin is not indicated for children under 18 years and old.