Contraindications : התוויות נגד

4.3. Contraindications
• Hypersensitivity to the active substance or to any of the        Methemoglobinemia excipients listed in section 6.1.                                  Methemoglobinemia which could be related to NADH
• Gastrointestinal hemorrhage, mechanical obstruction or           cytochrome b5 reductase deficiency has been gastro-intestinal perforation for which the stimulation of         reported. In such cases, metoclopramide should be gastrointestinal motility constitutes a risk.                      immediately and permanently discontinued and
• Confirmed or suspected pheochromocytoma, due to the risk         appropriate measures initiated (such as treatment with of severe hypertension episodes.                                   methylene blue).
• History of neuroleptic or metoclopramide-induced tardive Cardiac disorders dyskinesia.
There have been reports of serious cardiovascular
• Epilepsy (increased crises frequency and intensity).             undesirable effects including cases of circulatory
• Parkinson's disease.                                             collapse, severe bradycardia, cardiac arrest and QT
• Combination with levodopa or dopaminergic agonists (see          prolongation following administration of section 4.5)                                                       metoclopramide by injection, particularly via the
• Known history of methemoglobinemia with metoclopramide           intravenous route (see section 4.8).
or of NADH cytochrome- b5 reductase deficiency.
• Use in children less than 1 year of age due to an increased      Special care should be taken when administering risk of extrapyramidal disorders (see section 4.4).                metoclopramide, particularly via the intravenous route
• Metoclopramide S.A.L.F 10mg/2ml should not be used               to the elderly population, to patients with cardiac during the first three to four days following operations such as   conduction disturbances (including QT prolongation), pyloroplasty or gut anastomosis as vigorous muscular               patients with uncorrected electrolyte imbalance, contractions may adversely affect healing.                         bradycardia and those taking other drugs known to
• Metoclopramide should not be used during breast-feeding          prolong QT interval (e.g., class IA and III (see Section 4.6).                                                 antiarrhythmic drugs, tricyclic antidepressants, macrolides, antipsychotics (see section 4.8)).