Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1 Pharmacodynamic properties
Pharmaco-therapeutic group: Solvents and diluting agents incl. irrigating solutions ATC code: V07AB
Low concentration glucose solutions are suitable diluents for active substances because glucose, as a natural substrate of the cells in the organism, is ubiquitously metabolized.
Under physiological conditions glucose is the most important energy-supplying carbohydrate with a caloric value of 17 kJ/g or 4 kcal/g. In adults, the normal concentration of glucose in blood is reported to be 60 – 100 mg/100 ml, or 3.3 – 5.6 mmol/l (fasting).

Pharmacokinetic Properties

5.2 Pharmacokinetic Properties
On infusion glucose is first distributed in the intravascular space and then is taken up into the intracellular space.

In glycolysis, glucose is metabolized to pyruvate or to lactate. Lactate can be partially re- introduced into the glucose metabolism (CORI cycle). Under aerobic conditions pyruvate is completely oxidized to carbon dioxide and water. The final products of the complete oxidation of glucose are eliminated via the lungs (carbon dioxide) and the kidneys (water).