Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1     Pharmacodynamic properties
Pharmacotherapeutic group: other agents for oral local treatment, ATC code: A01AD02.
Clinical efficacy and safety
Clinical studies demonstrate that benzydamine is effective in relieving suffering from localized irritation processes of the mouth and pharynx. In addition, benzydamine possesses a moderate local anaesthetic effect.

Pharmacokinetic Properties

5.2     Pharmacokinetic properties
Absorption
The absorption through the mucosa of the mouth and pharynx was demonstrated by the presence of measurable quantities of benzydamine in the human plasma.
Distribution
About 2 hours after the 3 mg lozenge administration, benzydamine peak plasma values of 37.8 ng/ml with an AUC of 367 ng/ml*h were observed. However, these levels are not sufficient to produce pharmacological systemic effects.
When locally applied benzydamine has been shown to accumulate in inflamed tissues where it reaches effective concentrations because of its capacity to penetrate the epithelial lining.

Biotransformation and elimination
The excretion occurs mainly in the urine and mostly in the form of inactive metabolites or conjugation products.