Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

Mechanism of action
Terbinafine is an antifungal which has a broad spectrum of allylamine activity. It exerts a fungicidal action on dermatophytes.
Terbinafine interferes specifically with ergosterol biosynthesis in the fungal cell membrane at an early step. Inhibition of squalene epoxidase enzyme leads to ergosterol deficiency and accumulation of intracellular squalene, resulting in fungal cell lysis. Terbinafine inhibits squalene epoxidase in the fungal cell membrane. The enzyme squalene epoxidase is not linked to the cytochrome P450 system. Therefore, terbinafine has no effect on the metabolism of hormones or other medicinal products.
Minimum inhibitory concentration in vitro
Fungal species                µg/ml

Susceptible:
Trichophyton rubrum           0.003-0.006
T. mentagrophytes             0.003-0.01
T. tonsurans                  0.003
T. verrucosum                 0.003
T. schönleinii                0.006

Microsporum canis             0.006-0.01
M. versicolor                 0.003
M. gypseum                    0.006
Epidermophyton floccosum 0.003-0.006
5.1 Pharmacodynamics Missing information.
5.2 Clinical efficacy
Lamisil Spray may be recommended for short-term treatment.

Pharmacokinetic Properties