Interactions : אינטראקציות

7      DRUG INTERACTIONS

7.1    Cholestyramine
Concomitant administration of cholestyramine with EVISTA is not recommended. Although not specifically studied, it is anticipated that other anion exchange resins would have a similar effect. EVISTA should not be co-administered with other anion exchange resins [see Clinical Pharmacology (12.3)].

7.2    Warfarin
If EVISTA is given concomitantly with warfarin or other warfarin derivatives, prothrombin time should be monitored more closely when starting or stopping therapy with EVISTA [see Clinical Pharmacology (12.3)].

7.3    Other Highly Protein-Bound Drugs
EVISTA should be used with caution with certain other highly protein-bound drugs such as diazepam, diazoxide, and lidocaine.
Although not examined, EVISTA might affect the protein binding of other drugs. Raloxifene is more than 95% bound to plasma proteins [see Clinical Pharmacology (12.3)].

7.4    Systemic Estrogens
The safety of concomitant use of EVISTA with systemic estrogens has not been established and its use is not recommended.

7.5  Other Concomitant Medications
EVISTA can be concomitantly administered with ampicillin, amoxicillin, antacids, corticosteroids, and digoxin [see Clinical Pharmacology (12.3)].
The concomitant use of EVISTA and lipid-lowering agents has not been studied.