Posology : מינונים

4.2   Posology and method of administration

Posology
Primary vaccination:
Primary immunisation can be given as 3 doses at an interval of 1-2 months starting at the age of 2 or 3 months, or 2 doses at an interval of 2 months starting at the age of 3 months and a third dose at the age of 12 months.

Booster:
A fourth dose should be administered within the second year of life in children who received Pentaxim (DTaP-IPV/Hib) (or a diphtheria-tetanus-whole-cell or acellular pertussis-poliomyelitis vaccine, whether mixed or not with the freeze-dried conjugate Haemophilus influenzae type b vaccine) as a three-dose primary series between the ages of 2-6 months.

More data (e.g. epidemiological, clinical trial follow up) are required to establish the need for additional doses of acellular pertussis vaccines.

In a study involving 136 children, it was shown that Pentaxim can be administered simultaneously with measles-mumps-rubella vaccine (MMR II) at two separate injection sites.

Method of administration
Pentaxim must be administered intramuscularly. The recommended injection sites are the antero- lateral aspect of the upper thigh in infants and the deltoid muscle in older children.

The intradermal or intravenous routes must not be used. Do not administer by intravascular injection: ensure that the needle does not penetrate a blood vessel.
Pentaxim must be injected immediately after reconstitution of the freeze-dried powder by the suspension.

For instructions on the reconstitution of the medicinal product before administration, see section 6.6.