Pharmacological properties : תכונות פרמקולוגיות

Pharmacodynamic Properties

5.1   Pharmacodynamic properties
Pharmacotherapeutic group: drugs for gout, with no effect on uric acid metabolism.
ATC code: M04AC01
Mechanism of action
The mechanism of action of colchicine in the treatment of gout is not completely known. Urate crystals are phagocytosed by leukocytes. Hereby inflammatory factors are released. Colchicine inhibits these processes. Other properties of colchicine, such as interaction with microtubules, could also contribute to its action.

Onset of actions is approximately 12 hours after oral administration and is maximal after 1 to 2 days.

Pharmacokinetic Properties

5.2   Pharmacokinetic properties
Absorption
Colchicine is rapidly and almost completely absorbed after oral administration.
Maximum plasma concentrations are met usually after 30 to 120 minutes.

Distribution
Plasma protein binding of colchicine is approximately 30%. It accumulates in leucocytes.

Elimination
Colchicine is partially metabolized in the liver and then in part via the bile. It is largely excreted (80%) in unchanged form and as metabolites in the faeces. 10-20% is excreted in urine. The plasma half-life is 30-60 minutes and approximately 60 hours in leukocytes.

Paediatric population
No pharmacokinetics data are available in children.