Posology : מינונים

4.2     Posology and method of administration
Posology
Gout
The patient should be instructed to always have Colchicine at hand, so that therapy can be started at the first sign of an impending attack. Initiation of Colchicine therapy in the later stages of an attack may not completely abate the condition.
The initial dose to relieve an attack is 1 or 2 tablets, followed by 1 tablet each hour or 2 tablets every 2 hours, until the pain is relieved, or nausea, vomiting or diarrhea develops.
The total amount of colchicine usually required is variable. A course of therapy may range from 3-6 mg.
A total dose of 6 mg should not be exceeded. The course should not be repeated within three days.

Familial Mediterranean Fever (FMF)
The recommended dosage of colchicine for FMF in adults is 1 mg to 2 mg daily.

Colchicine should be increased as needed to control disease and as tolerated in increments of 0.25 mg/day to maximum recommended daily dose. If intolerable side effects develop, the dose should be decreased in increments of 0.25 mg/day. The total daily colchicine dose may be administered in one to two divided doses.
Renal Impairment:
For mild/moderate renal impairment (creatinine clearance 10-50 ml/minute), reduce dose or increase interval between doses (see also section Contraindications).

Elderly:
To be given with great care.

Children:
FMF: The recommended dosage of colchicine for FMF in pediatric patients 4 years of age and older is based on age. The following daily doses may be given as a single or divided dose twice daily:
Children 4 – 6 years: 0.25 mg to 1.5 mg daily
Children 6 – 12 years: 1 mg to 1.5 mg daily