Posology : מינונים

4.2    Posology and method of administration

Posology
The effective dose is usually within the range 5- 10 micrograms per kg bodyweight but higher doses may be necessary in some cases.
Paediatric population
Use in children: Emerade 500 micrograms is not recommended for use in children.

Children below 15 kg bodyweight
A dosage below 150 micrograms cannot be administered with sufficient accuracy in children weighing less than 15 kg and use is therefore not recommended unless under medical advice.

Children between 15 kg and 30 kg bodyweight
The usual dose is 150 micrograms.

Children over 30 kg bodyweight
The usual dose is 300 micrograms.
Adolescent patients over 30 kg bodyweight
The dosage recommendations for adult patients should be followed.

Use in adults
The recommended dose is 300 micrograms for individuals under 60 kg bodyweight. The recommended dose is 300 to 500 micrograms for individuals over 60 kg bodyweight, depending on clinical judgement.

An initial dose should be administered as soon as symptoms of anaphylaxis are recognised. In the absence of clinical improvement or if deterioration occurs, a second injection with an additional Emerade may be administered 5 – 15 minutes after the first injection. It is recommended that the patients are prescribed two Emerade pens which they should carry at all times.

Method of administration

For intramuscular injection only.
For single use.
Emerade is given intramuscularly as soon as the symptoms of anaphylactic shock arise. A poor outcome from anaphylaxis is associated with late administration of adrenaline.
Emerade must be injected in the outer side of the thigh.
Massaging around the injection area accelerates absorption.
The injection can be administered through clothing.

The patient/carer should be informed that following each use of Emerade:  They should call for immediate medical assistance, ask for an ambulance and state ‘anaphylaxis’ even if symptoms appear to be improving (see section 4.4).
 Conscious patients should preferably lie flat with feet elevated but sit up if they have breathing difficulties. Unconscious patients should be placed on their side in the recovery position.
 The patient should if possible remain with another person until medical assistance arrives.

For detailed instruction for use, refer to section 6.6.