Special Warning : אזהרת שימוש

4.4.   Special warnings and precautions for use
Cloxacillin should be given with caution to patients who have had previous hypersensitivity reactions (anaphylactic reactions) to the cephalosporin’s, penicillin’s or other drugs. If serious acute hypersensitivity or allergic reactions take place, patients should be treated with pressor amines, antihistamines corticosteroids and/or other emergency measures. Hypersensitivity reactions can sometimes be quite severe or even fatal. Even though anaphylaxis is more likely to happen after parenteral administration they have also been induced by oral administration as well.


Extensive use of antibiotics may encourage the overgrowth of non-susceptible organisms, including fungi. In such a case, appropriate measures should be taken. It is also advised to evaluate, periodically, the renal, hepatic and hematopoietic systems.


In streptococcal infections, treatment must be adequate to eliminate the organism (10 days minimum); otherwise the sequelae of streptococcal disease may occur. The cultures should be taken when the treatment has finished so to determine whether streptococci have been eradicated.


Use caution in administration in newborns due to the risk of hyperbilirubinemia due to binding competition on serum proteins (nuclear jaundice).
Penicillins are excreted largely unchanged by the kidney. Because renal function is incompletely developed in infants, the rate of elimination of the drug tends to be slow. Penicillin-type drugs should therefore be administered with caution, particularly in neonates, and organ system function should be evaluated frequently.

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