Interactions : אינטראקציות

4.5. Interactions with other medicinal products and other forms of interaction
Interaction resulting from concomitant use is not recommended.
Prostaglandins and their analogues
Prostaglandins and their analogues facilitate contraction of the myometrium, hence oxytocin can potentiate the uterine action of prostaglandins and analogues and vice versa (see section 4.3 Contraindications).
Drugs prolonging the QT interval
Oxytocin should be considered as potentially arrhythmogenic, particularly in patients with other risk factors for torsades de pointes, such as drugs, which prolong the QT interval or in patients with history of long QT syndrome (see section 4.4 Special warnings and precautions for use).
Interactions to be considered
Inhalation anaesthetics
Inhalation anaesthetics (e.g., cyclopropane, halothane, sevoflurane, desflurane) have a relaxing effect on the uterus and produce a notable inhibition of uterine tone, and thereby may diminish the uterotonic effect of oxytocin. Their concurrent use with oxytocin has also been reported to cause cardiac rhythm disturbances.
Vasoconstrictors/Sympathomimetics
Oxytocin may enhance the vasopressor effects of vasoconstrictors and sympathomimetics, even those contained in local anaesthetics.
Caudal anaesthetics
When given during or after caudal block anaesthesia, oxytocin may potentiate the pressor effect of sympathomimetic vasoconstrictor agents.