Posology : מינונים

4.2 Posology and method of administration
Chloramphenicol Fisiopharma is for intravenous use. The following dosages are recommended:
Adults and adolescents
The recommended dose for the treatment of most infections is 50-100 mg/kg/day divided in 4 daily doses (1 dose every 6 hours).
Infants up to 2 weeks
The recommended dose for the treatment of most infections is 25 mg/kg/day divided in 4 daily doses (1 dose every 6 hours).
For infants up to 1 week or weighing less than 2 kg, the recommended dose is 25 mg kg/day every 24 hours (once daily).
For infants over 1 week and weighing more than 2 kg, the recommended dose is 25 mg/kg/day divided in 2 daily doses (1 dose every 12 hours).
Infants over 2 weeks and children (up to 12 years)
The recommended dose for the treatment of most infections is 50 mg/kg/day divided in 4 daily doses (1 dose every 6 hours).
Impaired renal function
Although chloramphenicol does not significantly accumulate in presence of impaired renal function, the affected patients may have reduced ability to eliminate the drug and may require a dosage adjustment. Concentration of the drug in the blood should be frequently monitored to establish if the dosage adjustment is necessary.
Impaired hepatic function
Patients with impairment of hepatic function may have reduced ability to eliminate the drug and the dosage adjustment may be required. Concentration of the drug in the blood should be monitored to establish if the dosage adjustment is necessary.
In patients with impaired hepatic function, a loading dose of 1 g followed by 500 mg every 6 hours is recommended. Dosage of 500 mg every 6 hours is recommended in patients with liver cirrhosis.
In patients with jaundice, the dosage of 25 mg/kg/day must not be exceeded.
Patients on dialysis
The amount of drug removed by hemodialysis cannot justify a dosage adjustment in all cases.
The dosage should not be adjusted in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) or continuous arteriovenous haemofiltration (CAVH).
The solution for injection should be prepared extemporaneously by dissolving the powder in water for injections, saline or a 5% glucose solution, at the desired concentrations.