Special Warning : אזהרת שימוש

4.4 Special warnings and precautions for use
Treatment with the antibiotic should not be continued longer than the period indicated by the specific recommendation for each infection, possibly no longer than 2 weeks. Close monitoring of the blood levels during the treatment is recommended.
Administration of chloramphenicol in high dosages and for prolonged and repeated courses may cause the onset of aplastic anemia that may be detected weeks or months after the treatment discontinuation.
Chloramphenicol must be used with great caution in patients with blood dyscrasias. In prolonged or repeated treatment, the blood should be frequently monitored and the treatment should be interrupted immediately if the leukocytes drop below 4000 per mm3 and the granulocytes decrease by 40% (unless it is an inherent leukopenic infection such as fever typhoid); late complications are possible.
The use of chloramphenicol may also lead to a decrease in prothrombin time due to the inhibition of the intestinal flora producing vitamin K.
In patients with hepatic or renal insufficiency, dose adjustment may be necessary (see section 4.2 Posology and method of administration).
Treatment with chloramphenicol, as with other antibiotics, may result in superinfections due to insensitive bacterial agents or fungi.

Effects on Driving

4.7 Effects on ability to drive and use machines
Chloramphenicol Fisiopharma does not affect the ability to drive or use machines.