Posology : מינונים

4.2 Posology and method of administration
Oral use

Adults:
The dosage of one tablet, containing 2.5mg indapamide, to be taken daily in the morning.

Renal failure (see sections 4.3 and 4.4)
In severe renal failure (creatinine clearance below 30 ml/min), treatment is contraindicated.
Thiazides and related diuretics are fully effective only when renal function is normal or only minimally impaired.

Elderly (see section 4.4):
As for adults.
In the elderly, the plasma creatinine must be adjusted in relation to age, weight and gender. Elderly patients can be treated with indapamide when renal function is normal or only minimally impaired.

Hepatic impairment (see sections 4.3 and 4.4)
In severe hepatic impairment, treatment is contraindicated.

Children and adolescents:
Indapamide is not recommended for use in children and adolescents due to a lack of data on safety and efficacy.

The action of indapamide is progressive and the reduction of blood pressure may continue and not reach a maximum until several months after the start of therapy. A larger dose than 2.5mg indapamide daily is not recommended as there is no appreciable additional anti-hypertensive effect but a diuretic effect may become apparent. If a single daily tablet of indapamide does not achieve a sufficient reduction in blood pressure, another antihypertensive agent may be added such as beta-blockers, ACE inhibitors, methyldopa, clonidine and other adrenergic blocking agents.
The co-administration of indapamide with diuretics which may cause hypokalaemia is not recommended.
There is no evidence of rebound hypertension on withdrawal of indapamide.

Pamid tablets are for oral administration only. Pamid tablets can be taken with or without food.