Indications : התוויות

4.1      Therapeutic indications

Treatment of serious infections caused by susceptible organisms and also perioperatively for prophylaxis.
Treatment Respiratory tract:
Respiratory tract infections due to Streptococcus pneumoniae (formerly Diplococcus pneumoniae), Klebsiella species, Haemophilus influenzae, Staphylococcus aureus (penicillin- sensitive and penicillin-resistant) and group A B - hemolytic streptococci.
Cefazolin is effective in the eradication of streptococci from the nasopharynx. However data establishing the efficacy of cefazolin in the subsequent prevention of rheumatic fever are not available at present.
Urinary tract:

Infections due to Escherichia coli, Klebsiella species, Proteus mirabilis and some strains of enterobacter and enterococci.
Skin and skin structure:
-hemolytic beta Infections due to Staphylococcus aureus (penicillin-sensitive and penicillin- resistant) group A streptococci and other strains of streptococci.
Biliary tract:
Infections due to Escherichia coli various strains of streptococci, Proteus mirabilis, Klebsiella species and Staphylococcus aureus.
Bone and joint:
Infections due to Staphylococcus aureus.
Genital infections (i.e. prostatitis epididymitis) due to Escherichia coli, Proteus mirabilis, Klebsiella species and some strains of enterococci.
Septicemia due to Streptococcus pneumoniae (formerly Diplococcus pneumoniae), Staphylococcus aureus (penicillin-sensitive and penicillin-resistant), Proteus mirabilis, Escherichia coli and Klebsiella species.
Endocarditis caused by Staphylococcus aureus (penicillin-sensitive and penicillin-resistant) and group A beta-hemolytic streptococci.
Appropriate culture and susceptibility studies should be performed to determine the susceptibility of the causative organism to cefazolin.
Perioperative prophylaxis:
The prophylactic administraton of cefazolin perioperatively (preoperatively intraoperatively and postoperatively) may reduce the incidence of certain postoperative infections in patients undergoing surgical procedures (e.g. hysterectomy gastrointestinal surgery and transurethral prostatectomy) that are classified as contaminated or potentially contaminated.
The perioperative use of cefazolin may also be effective in surgical patients in whom infection at the operative site would present a serious risk (e.g. open-heart surgery and prosthetic arthroplasty).