Contraindications : התוויות נגד

4.3 Contraindications

Selgin is contra-indicated in patients with known hypersensitivity (including severe dizziness or hypotension) to selegiline or any of the excipients listed in section 6.1.
Selgin is contra-indicated in patients receiving treatment with serotonin-agonists (e.g. sumatriptan, naratriptan, zolmitriptan and rizatriptan).
Selegiline is also contra-indicated for concomitant use with pethidine and other opioids.
Selegiline should not be used in patients who are being treated with antidepressant drugs, including MAO inhibitors, tricyclic antidepressants, serotonin noradrenaline reuptake inhibitors (SNRI) (venlafaxine) and selective serotonin reuptake inhibitors (e.g citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine and sertraline. See section 4.5 interactions).
Selegiline should also not be used with other drugs which are also monoamine oxidase inhibitors, e.g. linezolid.
Selegiline should not be used in combination with sympathomimetics (see section 4.5).
Selegiline should not be used in patients with active duodenal or gastric ulcer.
Selegiline should not be used in patients with other extrapyramidal disorders not related to dopamine deficiency.
Selegiline in combination with levodopa is contra-indicated in severe cardiovascular disease, arterial hypertension, hyperthyroidism, phaeochromocytoma, narrow-angle glaucoma, prostatic adenoma with appearance of residual urine, tachycardia, arrhythmias, severe angina pectoris, psychoses, advanced dementia and thyrotoxicosis.