Posology : מינונים

4.2 Posology and method of administration

Posology
Children over 6 years old and adults: 10 ml once daily or 5 ml twice daily.
Special population
Elderly
Data do not suggest that the dose needs to be reduced in elderly subjects provided that the renal function is normal.
Renal impairment
There are no data to document the efficacy/safety ratio in patients with renal impairment. Since cetirizine is mainly eliminated via renal route (see section 5.2), in cases no alternative treatment can be used, the dosing intervals must be individualized according to renal function. Refer to the following table and adjust the dose as indicated. To use this dosing table, an estimate of the patient's creatinine clearance (CLcr) in ml/min is needed. The CLcr (ml/min) may be estimated from serum creatinine mg/dl) determination using the following formula:



Dosing adjustments for adult patients with impaired renal function

Group                         Creatinine clearance (ml/min)              Dosage and frequency 
Normal                                                    ≥80                               10 mg once daily Mild                                                   50 – 79                              10 mg once daily 
Moderate                                               30 – 49                               5 mg once daily 
Severe                                                   <30                             5 mg once every 2 days 
End-stage renal disease - Patients                       <10                                 Contraindicated undergoing dialysis


Hepatic impairment
No dose adjustment is needed in patients with solely hepatic impairment. In patients with hepatic impairment and renal impairment, adjustment of the dose is recommended (see Renal impairment above).
Paediatric population
Children 2-6 years old: 2.5 ml twice daily.

Children over 6 years old and adults: 10 ml once daily or 5 ml twice daily.

Method of administration:
The Syrup can be swallowed as such.