Pregnancy & Lactation : הריון/הנקה

4.6    Fertility, pregnancy and lactation
Pregnancy

Safety of the use of Etomidate-Lipuro during pregnancy has not yet been established.
Studies in animals have shown reproductive toxicity (see section 5.3). At maternally toxic doses in rats, decreased survival was noted.
Etomidate-Lipuro should be used during pregnancy only if the potential benefit justifies the risks to the foetus.
During obstetric anaesthesia, etomidate may cross the placenta. The Apgar scores of the newborns whose mothers have received etomidate are comparable with those of infants born after the use of other hypnotic agents.
A transient fall in cortisol levels lasting about 6 hours was observed in the neonate after the mother was given etomidate. The decreased values remained within the normal range.

Breast-feeding

Etomidate is excreted into human milk. Caution should be exercised when Etomidate- Lipuro is administered to a nursing mother.
If Etomidate-Lipuro must be given during the lactation period, nursing is to be interrupted and not to be resumed 24 hours after administration; breast milk secreted during this period must be discarded.